ORITAVANCIN (ORBACTIV) INFUSION		version 1/14/2022		

Appointment Requests 	

	
	Interval	Defer Until	Duration	
	☑	Referral to IV Infusion Room	Once	S	1 treatment	
		Status: Future, Expected: S, Expires: S+365, Clinic Performed
	Urgency of Scheduling: Routine		

Provider Communication 	

	
	Interval	Defer Until	Duration	
	☐	Provider communication	Every visit	S	Until discont'd	
		Exclusion criteria: Do NOT use if patient has osteomyelitis, diabetic foot infections, sepsis, confirmed/suspected bacteremia, necrotizing fasciitis, hemodynamic instability, or any other co-morbidities requiring inpatient admission.		
	☐	Provider communication	Every visit	S	Until discont'd	
		Indication for use: Indication for Use: Acute bacterial skin and skin structure infections (ABSSIs) - cellulitis, erysipelas, wound infection, or major cutaneous abscess with a minimum lesion surface area of approximately 75 cm2.		

Nursing Orders 	

	
	Interval	Defer Until	Duration	
	☐	Insert Peripheral IV or Access Portacath	Every visit	S	Until discont'd	
		No details available for preview		
	☐	dextrose 5% flush syringe 20 mL	Every visit	S	Until discont'd	
		20 mL, intravenous, PRN, line care, Starting when released, Until Discontinued		
	☐	dextrose 5% infusion 250 mL	Every visit	S	Until discont'd	
		250 mL, intravenous, at 30 mL/hr, once, Starting when released
	To keep vein open		
	☐	Vital signs - T/P/R/BP Per Unit Protocol	Every visit	S	Until discont'd	
		No details available for preview		
	☐	Nursing communication	Every visit	S	Until discont'd	
		If infusion-related reactions (itching, urticaria, flushing) occur, consider reducing the rate of infusion. ORBACTIV is NOT compatible with normal saline, flush infusion line with D5W ONLY.		
	☐	Nursing communication	Every visit	S	Until discont'd	
		Observe patient for 30 minutes following infusion for any kind of infusion-related reactions (pruritus, urticaria, flushing) and for signs of hypersensitivity reactions such as fever, chills, dyspnea, rash, hypotension, throat irritation.		
	☐	Nursing communication	Every visit	S	Until discont'd	
		If hypersensitivity/anaphylaxis occurs, stop infusion and notify physician immediately.		
	☐	HEParin, porcine injection 500 Units	Every visit	S	Until discont'd	
		500 Units, intra-catheter, once PRN, line care, Starting when released, Until Discontinued
	Heparin flush for Implanted Vascular Access Device Maintenance.		
	☐	Discontinue IV	Every visit	S	Until discont'd	
		No details available for preview		

Labs 	

	
	Interval	Defer Until	Duration	
	☐	CBC with platelet and differential	Every visit	S	Until discont'd	
		STAT, Normal, Clinic Collect		
	☐	Comprehensive metabolic panel	Every visit	S	Until discont'd	
		STAT, Normal, Clinic Collect		

Pre-Medications 	

	
	Interval	Defer Until	Duration	
	☐	diphenhydrAMINE (BENADRYL) tablet 25 mg	Every visit	S	Until discont'd	
		25 mg, oral, once, Starting when released		
	☐	diphenhydrAMINE (BENADRYL) injection 25 mg	Every visit	S	Until discont'd	
		25 mg, intravenous, once, Starting when released		
	☐	acetaminophen (TYLENOL) tablet 650 mg	Every visit	S	Until discont'd	
		650 mg, oral, once, Starting when released
	Maximum of 4 grams of acetaminophen per day from all sources. (Cirrhosis patients maximum: 2 grams per day from all sources).		
	☐	methylPREDNISolone sodium succinate (Solu-MEDROL) injection 40 mg	Every visit	S	Until discont'd	
		40 mg, intravenous, once, Starting when released		

Medications 	

	
	Interval	Defer Until	Duration	
	☐	oritavancin (ORBACTIV) 1,200 mg in dextrose 5% IVPB (RESTRICTED)	Once	S	1 treatment	
		1,200 mg, intravenous, Administer over: 3 Hours, once, Starting when released
	Do not infuse with other medications or electrolytes. Flush line before administration.
	Do not infuse with other medications or electrolytes. Flush line with D5W syringe before and after administration. Do NOT mix with NS saline-based solution.		

Hypersensitivity 	

	
	Interval	Defer Until	Duration	
	☐	acetaminophen (TYLENOL) tablet 650 mg	PRN	S	Until discont'd	
		650 mg, oral, every 4 hours PRN, mild pain (score 1-3), Starting when released, Until Discontinued
	Maximum of 4 grams of acetaminophen per day from all sources. (Cirrhosis patients maximum: 2 grams per day from all sources).		
	☐	diphenhydrAMINE (BENADRYL) tablet 25 mg	PRN	S	Until discont'd	
		25 mg, oral, every 6 hours PRN, itching, Starting when released, Until Discontinued		
	☐	diphenhydrAMINE (BENADRYL) injection 25 mg	PRN	S	Until discont'd	
		25 mg, intravenous, once PRN, for minor infusion reaction, Starting when released, Until Discontinued		
	☐	diphenhydrAMINE (BENADRYL) injection 50 mg	PRN	S	Until discont'd	
		50 mg, intravenous, once PRN, for severe infusion reaction, Starting when released, Until Discontinued		
	☐	epINEPHrine (ADRENALIN) injection 1 mg/mL 0.5 mg	PRN	S	Until discont'd	
		0.5 mL, subcutaneous, once PRN, anaphylaxis, Starting when released, Until Discontinued		
	☐	hydrocortisone sodium succinate (Solu-CORTEF) injection 100 mg	PRN	S	Until discont'd	
		100 mg, intravenous, once PRN, for infusion reaction, Starting when released, Until Discontinued		
	☐	promethazine (PHENERGAN) tablet 25 mg	PRN	S	Until discont'd	
		25 mg, oral, every 6 hours PRN, nausea, vomiting, Starting when released, Until Discontinued		
	☐	sodium chloride 0.9% infusion 250 mL	PRN	S	Until discont'd	
		250 mL, intravenous, once PRN, Hydration, Starting when released, Until Discontinued