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OP PRO00037422 - LU22 / TREATMENT	

Types:      Research Oncology Treatment
Synonyms:  LU22, TREATMENT, PRO00037422

Cycle 1	Repeat 1 time	Cycle length: 14 days	Day 0	Perform every 14 days x1			Research tolerance: -0/+0 days	Nursing Orders
  	ONC NURSING COMMUNCATION 101	Interval: --	Occurrences: --	Comments:	Physical Exam
			Nursing Orders
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
			Nursing Orders
  	ONC NURSING COMMUNCATION 101	Interval: --	Occurrences: --	Comments:	AEs and SAEs
		  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Concomitant Medications
			Nursing Orders
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Correlative Blood collection.

Blood will be drawn for detection changes in biomarkers on Day 0 (beginning of honokiol treatment) and Day 14 (EOT). Blood will be collected into standard vacutainer tubes (2 green top tubes, sodium heparin tubes). Samples will be frozen within 2 hours in a seahorse freezer
			Oral Chemotherapy
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Honokiol.

Honokiol will be administered orally starting on Day 0 at a dose of 2 capsules (250 mg/ capsule) per day for 2 weeks.
			Labs
  	NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	CBC with platelet count and differential WBC count will be performed at screening/baseline, Day 0 (beginning of honokiol treatment), Day 14 (EOT) and when clinically indicated. 
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --			Labs
  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --			Labs
  	ALKALINE PHOSPHATASE	Interval: --	Occurrences: --		  	ALT (SGPT)	Interval: --	Occurrences: --		  	AST (SGOT)	Interval: --	Occurrences: --				Days 1,2,3,4,5,...,12	Perform every 1 day x12			Research tolerance: -0/+0 days	Oral Chemotherapy
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Honokiol.

Honokiol will be administered orally starting on Day 0 at a dose of 2 capsules (250 mg/ capsule) per day for 2 weeks.
					
Day 14	Repeat 1 time	Cycle length: 1 day	Day 14	Perform every 14 days x1			Research tolerance: -3/+3 days	Nursing Orders
  	ONC NURSING COMMUNCATION 101	Interval: --	Occurrences: --	Comments:	Physical Exam
			Nursing Orders
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
			Nursing Orders
  	ONC NURSING COMMUNCATION 101	Interval: --	Occurrences: --	Comments:	AEs and SAEs
		  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Concomitant Medications
			Nursing Orders
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Correlative Blood collection.

Blood will be drawn for detection changes in biomarkers on Day 0 (beginning of honokiol treatment) and Day 14 (EOT). Blood will be collected into standard vacutainer tubes (2 green top tubes, sodium heparin tubes). Samples will be frozen within 2 hours in a seahorse freezer
			Oral Chemotherapy
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Honokiol.

Honokiol will be administered orally starting on Day 0 at a dose of 2 capsules (250 mg/ capsule) per day for 2 weeks.
			Labs
  	NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	CBC with platelet count and differential WBC count will be performed at screening/baseline, Day 0 (beginning of honokiol treatment), Day 14 (EOT) and when clinically indicated. 
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --			Labs
  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --			Labs
  	ALKALINE PHOSPHATASE	Interval: --	Occurrences: --		  	ALT (SGPT)	Interval: --	Occurrences: --		  	AST (SGOT)	Interval: --	Occurrences: --					
Day 15	Repeat 1 time	Cycle length: 1 day	Day 15	Perform every 14 days x1			Research tolerance: -0/+0 days	Nursing Orders
  	ONC NURSING COMMUNCATION 101	Interval: --	Occurrences: --	Comments:	AEs and SAEs
		  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Concomitant Medications
			Procedures
  	BIOPSY	Interval: --	Occurrences: --	Comments:	Biopsy (Correlative Tissue Collection).

from surgical pathology from the Standard of Care resection. Tissue samples will be stored in the Houston Methodist biorepository in Fondren 7 (F774) right after being collected
			Oral Chemotherapy
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Honokiol.

Honokiol will be administered orally starting on Day 0 at a dose of 2 capsules (250 mg/ capsule) per day for 2 weeks.
					
Day 44 (Follow-up)	Repeat 1 time	Cycle length: 14 days	Day 44	Perform every 14 days x1			Research tolerance: -3/+3 days	Nursing Orders
  	ONC NURSING COMMUNCATION 101	Interval: --	Occurrences: --	Comments:	Physical Exam
			Nursing Orders
  	ONC NURSING COMMUNCATION 101	Interval: --	Occurrences: --	Comments:	AEs and SAEs
		  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Concomitant Medications
			Oral Chemotherapy
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Honokiol.

Honokiol will be administered orally starting on Day 0 at a dose of 2 capsules (250 mg/ capsule) per day for 2 weeks.
			Labs
  	NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	CBC with platelet count and differential WBC count will be performed at screening/baseline, Day 0 (beginning of honokiol treatment), Day 14 (EOT) and when clinically indicated. 
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --			Labs
  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --			Labs
  	ALKALINE PHOSPHATASE	Interval: --	Occurrences: --		  	ALT (SGPT)	Interval: --	Occurrences: --		  	AST (SGOT)	Interval: --	Occurrences: --