LEUPROLIDE DEPOT (LUPRON) Q12WEEKS		version 5/20/2024		

Nursing Orders 	

	
	Interval	Defer Until	Duration	
	☐	Treatment conditions	Every 84 days	S	Until discont'd	
		Once Starting when released
	Hold intramuscular treatment and notify provider if patient is on warfarin and most recent INR is greater than 2.9. If the patient is on a low molecular weight heparin or an anti-platelet agent, apply pressure to site of injection for 5-10 minutes.		

Supportive Care 	

	
	Interval	Defer Until	Duration	
	☐	leuprolide (LUPRON) depot injection 11.25 mg (RESTRICTED)	Every 84 days	S	Until discont'd	
		22.5 mg, intramuscular, once, Starting at treatment start time
	Wear gloves with administration.
	Administer as a single injection into the gluteal area, anterior thigh, or deltoid.		

Emergency Medications 	

	
	Interval	Defer Until	Duration	
	☐	diphenhydrAMINE (BENADRYL) injection 25-50 mg	PRN	S	Until discont'd	
		25-50 mg, intravenous, every 6 hours PRN, for moderate signs of anaphylaxis, i.e. rash, redness or flushing, hives or welts, mild edema, Starting when released, for 2 doses		
	☐	hydrocortisone sodium succinate (Solu-CORTEF) injection 100 mg	PRN	S	Until discont'd	
		100 mg, intravenous, once PRN, for moderate signs of anaphylaxis, i.e. rash, redness or flushing, hives or welts, mild edema, Starting when released, Until Discontinued		
	☐	EPINEPHrine (ADRENALIN) injection 0.3 mg	PRN	S	Until discont'd	
		0.3 mg, intramuscular, once PRN, anaphylaxis, Starting when released, Until Discontinued