CRIZANLIZUMAB (ADAKVEO) INFUSION		version 2/27/2025		

Appointment Requests 	

	
	Interval	Defer Until	Duration	
	☑	Referral to IV Infusion Room Appointment request for initial doses.	Every 2 weeks	S	2 treatments	
		Status: Future, Expected: S, Expires: S+365, Clinic Performed
	Urgency of Scheduling: Routine
	Appointment request for initial doses.		
	☑	Referral to IV Infusion Room Appointment request for subsequent doses.	Every 4 weeks	S+42	 treatments	
		Status: Future, Expected: S, Expires: S+365, Clinic Performed
	Urgency of Scheduling: Routine
	Appointment request for subsequent doses.		

Nursing Orders 	

	
	Interval	Defer Until	Duration	
	☐	Insert Peripheral IV or Access Portacath	Every visit	S	Until discont'd	
		No details available for preview		
	☐	Nursing communication	Every visit	S	Until discont'd	
		Draw blood in a Sodium Citrate (blue top) specimen tube. Crizanlizumab (ADAKVEO) can interfere with automated platelet counts (platelet clumping).		
	☐	Vital signs - T/P/R/BP Per Unit Protocol	Every visit	S	Until discont'd	
		No details available for preview		
	☐	sodium chloride 0.9% flush 25 mL	Every visit	S	Until discont'd	
		25 mL, intravenous, every 8 hours, Starting when released
	Flush line with at least 25 mL of NS or D5W (please order separately) post completion of Crizanlizumab infusion		
	☐	Discontinue IV	Every visit	S	Until discont'd	
		No details available for preview		

Labs 	

	
	Interval	Defer Until	Duration	
	☐	CBC with platelet and differential	Every visit	S	Until discont'd	
		STAT, Normal, Clinic Collect
	Draw blood in a Sodium Citrate (blue top) specimen tube. Crizanlizumab (ADAKVEO) can interfere with automated platelet counts (platelet clumping).		

Medications 	

	
	Interval	Defer Until	Duration	
	☐	crizanlizumab-tmca (ADAKVEO) 5 mg/kg in sodium chloride 0.9% 100 mL IVPB (RESTRICTED)	Every 2 weeks	S	2 treatments	
		5 mg/kg, intravenous, Administer over: 30 Minutes, once, Starting when released
	Administer with 0.22 micron in-line filter.  Do not shake. Do not mix with other medications. After infusion is complete, flush the line with GREATER or Equal to 25 mL of NS or D5W
	Administer through 0.2 micron filter. After administration, flush line with at least 25 mL of 0.9% Sodium Chloride or 5% Dextrose Injection 		
	☐	crizanlizumab-tmca (ADAKVEO) 5 mg/kg in sodium chloride 0.9% 100 mL IVPB (RESTRICTED)	Every 4 weeks	S+42	Until discont'd	
		5 mg/kg, intravenous, Administer over: 30 Minutes, once, Starting when released
	Administer with 0.22 micron in-line filter.  Do not shake. Do not mix with other medications. After infusion is complete, flush the line with GREATER or Equal to 25 mL of NS or D5W
	Administer through 0.2 micron filter. After administration, flush line with at least 25 mL of 0.9% Sodium Chloride or 5% Dextrose Injection 		

Hypersensitivity 	

	
	Interval	Defer Until	Duration	
	☐	hydrocortisone sodium succinate (Solu-CORTEF) injection 100 mg	PRN	S	Until discont'd	
		100 mg, intravenous, once PRN, for infusion reaction, Starting when released, Until Discontinued		
	☐	diphenhydrAMINE (BENADRYL) injection 25 mg	PRN	S	Until discont'd	
		25 mg, intravenous, once PRN, for minor infusion reaction, Starting when released, Until Discontinued		
	☐	epINEPHrine (ADRENALIN) injection 1 mg/mL 0.5 mg	PRN	S	Until discont'd	
		0.5 mL, subcutaneous, once PRN, anaphylaxis, Starting when released, Until Discontinued