ADAMTS13 (ADZYNMA) WEEKLY INFUSION		version 2/27/2025		

Appointment Requests 	

	
	Interval	Defer Until	Duration	
	☑	Referral to IV Infusion Room	Every 7 days	S	 treatments	
		Status: Future, Expected: S, Expires: S+365, Clinic Performed
	Urgency of Scheduling: Routine		

Labs 	

	
	Interval	Defer Until	Duration	
	☐	Comprehensive metabolic panel	Once	S	1 treatment	
		Routine, Normal, Clinic Collect		
	☐	CBC with platelet and differential	Every visit	S	Until discont'd	
		Routine, Normal, Clinic Collect		
	☐	LDH	Every visit	S	Until discont'd	
		Routine, Normal, Clinic Collect		
	☐	ADAMTS13 activity with reflex to inhibitor	Every visit	S	Until discont'd	
		Routine, Normal, Clinic Collect		

Nursing Orders 	

	
	Interval	Defer Until	Duration	
	☐	Nursing communication	Every visit	S	Until discont'd	
		Use ADZYNMA within 3 hours after reconstitution and keep at room temperature not to exceed 86°F/30°C.
	Do not store at any other temperature. 
	Discard any unused reconstituted product if not used within 3 hours after reconstitution.		
	☐	Nursing communication	Every visit	S	Until discont'd	
		Do not administer ADZYNMA in the same infusion line as other medications.		
	☐	Nursing communication	Every visit	S	 treatments	
		Monitor patient for: 
	Abdominal pain, diarrhea, nausea, vomiting; 
	Headache, migraine, dizziness; 
	Signs of upper respiratory infection (fever, cough, runny nose); 
	Hypersensitivity and anaphylactic reactions (tachycardia, chest tightness, wheezing, respiratory distress, hypotension, hives, itching, angioedema, lethargy, nausea, vomiting, tingling or prickling sensation, restlessness).		
	☐	Insert Peripheral IV or Access Portacath	Every visit	S	Until discont'd	
		No details available for preview		
	☐	Vital signs - T/P/R/BP	Every visit	S	Until discont'd	
		Clinic Performed, Normal		
	☐	sodium chloride 0.9% flush 10 mL	Every visit	S	Until discont'd	
		10 mL, intravenous, PRN, line care, Starting when released, for 10 doses		
	☐	sodium chloride 0.9 % infusion	Every visit	S	Until discont'd	
		250 mL, intravenous, at 30 mL/hr, PRN, Flush bag, Starting when released, Until Discontinued		
	☐	HEParin, porcine injection 500 Units	Every visit	S	Until discont'd	
		500 Units, intra-catheter, once PRN, line care, Starting when released, Until Discontinued
	Heparin flush for Implanted Vascular Access Device Maintenance.		
	☐	Discontinue IV	Every visit	S	Until discont'd	
		No details available for preview		

Medications 	

	
	Interval	Defer Until	Duration	
	☐	ADAMTS13, recombinant-krhn (ADZYNMA) infusion syringe (RESTRICTED)	Every 7 days	S	 treatments	
		40 Units/kg, intravenous, at 180 mL/hr, once, Starting when released
	For IV infusion at a rate of 2 - 4 mL per minute
	Use ADAMTS13, recombinant-krhn (ADZYNMA) within 3 hours after reconstitution and keep at room temperature not to exceed 86°F/30°C.
	Do not store at any other temperature. 
	Discard any unused reconstituted product if not used within 3 hours after reconstitution.
	For IV infusion at a rate of 2 - 4 mL per minute 

	Use within 3 hours after reconstitution and keep at room temperature. Protect from light.

	In accordance with P&T medication policy, pharmacists will round the dose to the nearest available vial size, when the change is less than or equal to 10% of the total ordered dose.

	

			

Hypersensitivity 	

	
	Interval	Defer Until	Duration	
	☐	acetaminophen (TYLENOL) tablet 650 mg	PRN	S	Until discont'd	
		650 mg, oral, every 4 hours PRN, mild pain (score 1-3), Starting when released, Until Discontinued
	Maximum of 4 grams of acetaminophen per day from all sources. (Cirrhosis patients maximum: 2 grams per day from all sources).		
	☐	diphenhydrAMINE (BENADRYL) tablet 25 mg	PRN	S	Until discont'd	
		25 mg, oral, every 6 hours PRN, itching, Starting when released, Until Discontinued		
	☐	diphenhydrAMINE (BENADRYL) injection 25 mg	PRN	S	Until discont'd	
		25 mg, intravenous, once PRN, for minor infusion reaction, Starting when released, Until Discontinued		
	☐	diphenhydrAMINE (BENADRYL) injection 50 mg	PRN	S	Until discont'd	
		50 mg, intravenous, once PRN, for severe infusion reaction, Starting when released, Until Discontinued		
	☐	epINEPHrine (ADRENALIN) injection 1 mg/mL	PRN	S	Until discont'd	
		0.5 mL, subcutaneous, once PRN, anaphylaxis, Starting when released, Until Discontinued		
	☐	hydrocortisone sodium succinate (Solu-CORTEF) injection 100 mg	PRN	S	Until discont'd	
		100 mg, intravenous, once PRN, for infusion reaction, Starting when released, Until Discontinued		
	☐	promethazine (PHENERGAN) tablet 25 mg	PRN	S	Until discont'd	
		25 mg, oral, every 6 hours PRN, nausea, vomiting, Starting when released, Until Discontinued		
	☐	sodium chloride 0.9 % infusion	PRN	S	Until discont'd	
		250 mL, intravenous, once PRN, Hydration, Starting when released, Until Discontinued