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OP RESEARCH PRO00039131 V940-009 NEO-ADJUVANT SCREENING KIM	

Types:      Research Oncology Treatment
Synonyms:  

Cycle 1	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1			Research tolerance: -0/+0 days	Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Please refer to Study Protocol for any questions or discrepancies. See Schedule of Events Calendar for sequence of diagnostic tests, examinations, and treatment administration: See Safety Parameters-for Toxicity Management and Dose Modification Guidelines: Protocol Access hyperlink: Protocol Amendment English 30 Jul 2025 (VV-TMF-23678288).pdf
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Dose Modifications and Toxicity Management for Immune-related AEs Associated with Pembrolizumab: Refer to Protocol Section 6.6.2 Pg 82-87  Immune-Related Events and Dose Modification (Withhold, Treat, Discontinue)
Dose Modification and Toxicity Management of AEs Associated with Chemotherapy: Refer to Protocol Section 6.6.3 Pg 87-92 Chemotherapy Dose Modifications
Protocol Access Hyperlink:  Protocol Amendment English 30 Jul 2025 (VV-TMF-23678288).pdf
			Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Full Physical exam. 
Perform within days -28 to -1.
		  	HEIGHT AND WEIGHT	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Temperature, pulse, respirations and BP. 
Perform within days -28 to -1.
		  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	ECOG. 
Perform within days -28 to -1.
			Imaging
  	ECG 12-LEAD	Interval: --	Occurrences: --	Comments:	- Perform within days -28 to -1.
- A 6 lead is allowed if institutional SOC.
		  	CT CHEST W WO CONTRAST ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	Place order for MRI if clinically appropriate.
		  	MRI BRAIN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	- Place order for CT if clinically appropriate. 
- Perform within 42 days before enrollment. 
- Rule out metastasis.
		  	NM BONE SCAN WHOLE BODY	Interval: --	Occurrences: --	Comments:	- Whole body FDG-PET scan. 
- Perform within 42 days before enrollment. 
- At the minimum, it must include skull base to mid-thigh.
			Labs
  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	HIV 1/2 ANTIGEN/ANTIBODY, FOURTH GENERATION, WITH REFLEXES	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	HEPATITIS B SURFACE ANTIGEN	Interval: --	Occurrences: --	Comments:	- Perform within days -28 to -1. 
- Place order for HBV DNA if clinically appropriate.
- Only if required per Section 5.2 and/or Appendix 7 in the protocol.
		  	HEPATITIS C VIRUS (HCV) ANTIBODY WITH REFLEX TO PCR	Interval: --	Occurrences: --	Comments:	- Perform within days -28 to -1. 
- Place order for HCV RNA if clinically appropriate.
		  	FOLLICLE STIMULATING HORMONE	Interval: --	Occurrences: --	Comments:	- Perform within days -28 to -1. 
- As required for PONCBP.
		  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	- Perform within days -28 to -1. 
- Per institutional SOC; if blood or protein is abnormal perform microscopic exam.
		  	T3	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	T4	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	THYROID STIMULATING HORMONE	Interval: --	Occurrences: --	Comments:	Perform within days -28 to -1.
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	- Perform within days -28 to -1. 
- Negative test required within 24 hr (urine test) or 72 hr (serum test) before dosing. 
- See Section 8.3.5 in the protocol.