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IP APML4 INDUCTION	

Types:      ONCOLOGY TREATMENT
Synonyms:  ACUTE, PROMYEL, APL, ATRA, IDAR, ATO, ARSE, APML, ARSENIC

Cycle 1	Repeat 1 time	Cycle length: 45 days	Day 1	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Provider Communication
  	ONC PROVIDER COMMUNICATION 5	Interval: Once	Occurrences: --	Comments:	Use baseline weight to calculate dose. Adjust dose for weight gains/losses of greater than or equal to 10%.
			Provider Communication
  	ONC PROVIDER COMMUNICATION	Interval: Once	Occurrences: --	Comments:	Verify Ejection Fraction prior to Cycle 1.  Ejection Fraction: ***% on *** (date).

If patient has not had a recent MUGA or ECHO, order one via order entry. A baseline cardiac evaluation with a MUGA scan or an ECHO is recommended, especially in patients with risk factors for increased cardiac toxicity. Repeated MUGA or ECHO determinations of LVEF should be performed, particularly with higher, cumulative anthracycline doses.

			Provider Communication
  	ONC PROVIDER COMMUNICATION 64	Interval: Once	Occurrences: --	Comments:	Verify Hep B panel status prior to cycle. Date *** of panel. Result positive/negative/pending/unknown:22867

The required components for the hepatitis B panel includes: Hepatitis B surface antigen (HBsAg), total hepatitis B core antibody (anti-HBc), and hepatitis B antibody (anti-HBs).
			Supportive Care
  	predniSONE (DELTASONE) tablet 1 mg/kg (Treatment Plan)	Dose: 1 mg/kg	Route: oral	daily for 10 doses				Instructions:	Continue until WBC count is less than 1000, or resolution of differentiation syndrome.			Chemotherapy
  	tretinoin (VESANOID) chemo capsule 22.5 mg/m2 (Treatment Plan)	Dose: 22.5 mg/m2	Route: oral	2 times daily with meals	Start: S			Instructions:	DO NOT CRUSH, CHEW, DISSOLVE, OR MANIPULATE CAPSULE IN ANY WAY.  Administer with meals.

Round to nearest 10 mg capsule (total daily dose = 45 mg/m2).				Day 2	Perform every 1 day x1		Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
☑	ondansetron (ZOFRAN) IV 16 mg	Dose: 16 mg	Route: intravenous	once for 1 dose	Start: S				☐	ondansetron (ZOFRAN), dexamethasone (DECADRON) in sodium chloride 0.9% 50 mL IVPB	Dose: --	Route: intravenous	once over 10 Minutes for 1 dose	Start: S			Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ONDANSETRON HCL 2 MG/ML INTRAVENOUS SOLUTION	Medications	 	Main Ingredient	No	DEXAMETHASONE SODIUM PHOSPHATE 10 MG/ML INJECTION SOLUTION	Medications	 	Yes	No	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	Base	50 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	50 mL	No	Yes			☐	ondansetron (ZOFRAN) tablet 16 mg	Dose: 16 mg	Route: oral	once for 1 dose	Start: S				☐	dexamethasone (DECADRON) tablet 12 mg	Dose: 12 mg	Route: oral	once for 1 dose	Start: S				☐	fosaprepitant (EMEND) IVPB 150 mg	Dose: 150 mg	Route: intravenous	once over 30 Minutes for 1 dose	Start: S					Provider Communication
  	ONC PROVIDER COMMUNICATION 25	Interval: Once	Occurrences: --	Comments:	Reduce dose of idarubicin to 9 mg/m2 for patients ages 61 - 70. Reduce dose of idarubicin to 6 mg/m2 for patients ages greater than 70 years old.
			Chemotherapy
  	IDArubicin (IDAmycin) 12 mg/m2 in sodium chloride 0.9 % 50 mL chemo IVPB	Dose: 12 mg/m2	Route: intravenous	once over 15 Minutes for 1 dose			Offset: 30 Minutes	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	IDARUBICIN 1 MG/ML INTRAVENOUS SOLUTION	Medications	12 mg/m2	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	50 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	 	No	Yes				Hematology & Oncology Hypersensitivity Reaction Standing Order
  	ONC NURSING COMMUNICATION 82	Interval: Until discontinued	Occurrences: --	Comments:	Grade 1 - MILD Symptoms (cutaneous and subcutaneous symptoms only - itching, flushing, periorbital edema, rash, or runny nose)
1. Stop the infusion.
2. Place the patient on continuous monitoring.
3. Obtain vital signs.
4. Administer Normal Saline at 50 mL per hour using a new bag and new intravenous tubing.
5. If greater than or equal to 30 minutes since the last dose of Diphenhydramine, administer Diphenhydramine 25 mg intravenous once.
6. If less than 30 minutes since the last dose of Diphenhydramine, administer Cetirizine 10 mg orally and Famotidine 20 mg intravenous once.
7. Notify the treating physician.
8. If no improvement after 15 minutes, advance level of care to Grade 2 (Moderate) or Grade 3 (Severe).
9. Assess vital signs every 15 minutes until resolution of symptoms or otherwise ordered by covering physician.
		  	ONC NURSING COMMUNICATION 83	Interval: Until discontinued	Occurrences: --	Comments:	Grade 2 - MODERATE Symptoms (cardiovascular, respiratory, or gastrointestinal symptoms - shortness of breath, wheezing, nausea, vomiting, dizziness, diaphoresis, throat or chest tightness, abdominal or back pain)
1. Stop the infusion.
2. Notify the CERT team and treating physician immediately.
3. Place the patient on continuous monitoring.
4. Obtain vital signs.
5. Administer Oxygen at 2 L per minute via nasal cannula. Titrate to maintain O2 saturation of greater than or equal to 92%.
6. Administer Normal Saline at 150 mL per hour using a new bag and new intravenous tubing.
7. Administer Hydrocortisone 100 mg intravenous (if patient has allergy to Hydrocortisone, please administer Dexamethasone 4 mg intravenous), Cetirizine 10 mg orally and Famotidine 20 mg intravenous once.
8. If no improvement after 15 minutes, advance level of care to Grade 3 (Severe).
9. Assess vital signs every 15 minutes until resolution of symptoms or otherwise ordered by covering physician.
		  	ONC NURSING COMMUNICATION 4	Interval: Until discontinued	Occurrences: --	Comments:	Grade 3 – SEVERE Symptoms (hypoxia, hypotension, or neurologic compromise – cyanosis or O2 saturation less than 92%, hypotension with systolic blood pressure less than 90 mmHg, confusion, collapse, loss of consciousness, or incontinence)
1. Stop the infusion.
2. Notify the CERT team and treating physician immediately.
3. Place the patient on continuous monitoring.
4. Obtain vital signs.
5. If heart rate is less than 50 or greater than 120, or blood pressure is less than 90/50 mmHg, place patient in reclined or flattened position.
6. Administer Oxygen at 2 L per minute via nasal cannula. Titrate to maintain O2 saturation of greater than or equal to 92%.
7. Administer Normal Saline at 1000 mL intravenous bolus using a new bag and new intravenous tubing.
8. Administer Hydrocortisone 100 mg intravenous (if patient has allergy to Hydrocortisone, please administer Dexamethasone 4 mg intravenous) and Famotidine 20 mg intravenous once.
9. Administer Epinephrine (1:1000) 0.3 mg subcutaneous.
10. Assess vital signs every 15 minutes until resolution of symptoms or otherwise ordered by covering physician.
		  	diphenhydrAMINE (BENADRYL) injection 25 mg	Dose: 25 mg	Route: intravenous	PRN	Start: S				  	cetirizine (ZyrTEC) tablet 10 mg	Dose: 10 mg	Route: oral	PRN	Start: S				  	famotidine (PEPCID) injection 20 mg	Dose: 20 mg	Route: intravenous	PRN	Start: S				  	hydrocortisone sodium succinate (Solu-CORTEF) injection 100 mg	Dose: 100 mg	Route: intravenous	PRN					  	dexAMETHasone (DECADRON) IV 4 mg	Dose: 4 mg	Route: intravenous	PRN	Start: S				  	epINEPHrine (ADRENALIN) 1 mg/1 mL injection 0.3 mg	Dose: 0.3 mg	Route: subcutaneous	PRN	Start: S					Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 4	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
☑	ondansetron (ZOFRAN) IV 16 mg	Dose: 16 mg	Route: intravenous	once for 1 dose	Start: S				☐	ondansetron (ZOFRAN), dexamethasone (DECADRON) in sodium chloride 0.9% 50 mL IVPB	Dose: --	Route: intravenous	once over 10 Minutes for 1 dose	Start: S			Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ONDANSETRON HCL 2 MG/ML INTRAVENOUS SOLUTION	Medications	 	Main Ingredient	No	DEXAMETHASONE SODIUM PHOSPHATE 10 MG/ML INJECTION SOLUTION	Medications	 	Yes	No	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	Base	50 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	50 mL	No	Yes			☐	ondansetron (ZOFRAN) tablet 16 mg	Dose: 16 mg	Route: oral	once for 1 dose	Start: S				☐	dexamethasone (DECADRON) tablet 12 mg	Dose: 12 mg	Route: oral	once for 1 dose	Start: S				☐	fosaprepitant (EMEND) IVPB 150 mg	Dose: 150 mg	Route: intravenous	once over 30 Minutes for 1 dose	Start: S					Chemotherapy
  	IDArubicin (IDAmycin) 12 mg/m2 in sodium chloride 0.9 % 50 mL chemo IVPB	Dose: 12 mg/m2	Route: intravenous	once over 15 Minutes for 1 dose			Offset: 30 Minutes	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	IDARUBICIN 1 MG/ML INTRAVENOUS SOLUTION	Medications	12 mg/m2	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	50 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	 	No	Yes					Day 6	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
☑	ondansetron (ZOFRAN) IV 16 mg	Dose: 16 mg	Route: intravenous	once for 1 dose	Start: S				☐	ondansetron (ZOFRAN), dexamethasone (DECADRON) in sodium chloride 0.9% 50 mL IVPB	Dose: --	Route: intravenous	once over 10 Minutes for 1 dose	Start: S			Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ONDANSETRON HCL 2 MG/ML INTRAVENOUS SOLUTION	Medications	 	Main Ingredient	No	DEXAMETHASONE SODIUM PHOSPHATE 10 MG/ML INJECTION SOLUTION	Medications	 	Yes	No	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	Base	50 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	50 mL	No	Yes			☐	ondansetron (ZOFRAN) tablet 16 mg	Dose: 16 mg	Route: oral	once for 1 dose	Start: S				☐	dexamethasone (DECADRON) tablet 12 mg	Dose: 12 mg	Route: oral	once for 1 dose	Start: S				☐	fosaprepitant (EMEND) IVPB 150 mg	Dose: 150 mg	Route: intravenous	once over 30 Minutes for 1 dose	Start: S					Chemotherapy
  	IDArubicin (IDAmycin) 12 mg/m2 in sodium chloride 0.9 % 50 mL chemo IVPB	Dose: 12 mg/m2	Route: intravenous	once over 15 Minutes for 1 dose			Offset: 30 Minutes	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	IDARUBICIN 1 MG/ML INTRAVENOUS SOLUTION	Medications	12 mg/m2	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	50 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	 	No	Yes					Day 8	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
☑	ondansetron (ZOFRAN) IV 16 mg	Dose: 16 mg	Route: intravenous	once for 1 dose	Start: S				☐	ondansetron (ZOFRAN), dexamethasone (DECADRON) in sodium chloride 0.9% 50 mL IVPB	Dose: --	Route: intravenous	once over 10 Minutes for 1 dose	Start: S			Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ONDANSETRON HCL 2 MG/ML INTRAVENOUS SOLUTION	Medications	 	Main Ingredient	No	DEXAMETHASONE SODIUM PHOSPHATE 10 MG/ML INJECTION SOLUTION	Medications	 	Yes	No	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	Base	50 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	50 mL	No	Yes			☐	ondansetron (ZOFRAN) tablet 16 mg	Dose: 16 mg	Route: oral	once for 1 dose	Start: S				☐	dexamethasone (DECADRON) tablet 12 mg	Dose: 12 mg	Route: oral	once for 1 dose	Start: S				☐	fosaprepitant (EMEND) IVPB 150 mg	Dose: 150 mg	Route: intravenous	once over 30 Minutes for 1 dose	Start: S					Chemotherapy
  	IDArubicin (IDAmycin) 12 mg/m2 in sodium chloride 0.9 % 50 mL chemo IVPB	Dose: 12 mg/m2	Route: intravenous	once over 15 Minutes for 1 dose			Offset: 30 Minutes	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	IDARUBICIN 1 MG/ML INTRAVENOUS SOLUTION	Medications	12 mg/m2	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	50 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	 	No	Yes					Day 9	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
☑	ondansetron (ZOFRAN) IV 16 mg	Dose: 16 mg	Route: intravenous	once for 1 dose	Start: S				☐	ondansetron (ZOFRAN), dexamethasone (DECADRON) in sodium chloride 0.9% 50 mL IVPB	Dose: --	Route: intravenous	once over 10 Minutes for 1 dose	Start: S			Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ONDANSETRON HCL 2 MG/ML INTRAVENOUS SOLUTION	Medications	 	Main Ingredient	No	DEXAMETHASONE SODIUM PHOSPHATE 10 MG/ML INJECTION SOLUTION	Medications	 	Yes	No	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	Base	50 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	50 mL	No	Yes			☐	ondansetron (ZOFRAN) tablet 16 mg	Dose: 16 mg	Route: oral	once for 1 dose	Start: S				☐	dexamethasone (DECADRON) tablet 12 mg	Dose: 12 mg	Route: oral	once for 1 dose	Start: S				☐	fosaprepitant (EMEND) IVPB 150 mg	Dose: 150 mg	Route: intravenous	once over 30 Minutes for 1 dose	Start: S					Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes				Electrolyte Replacement
  	TREATMENT CONDITIONS 39	Interval: --	Occurrences: --	Comments:	Potassium (Normal range 3.5 to 5.0mEq/L)
o	Serum potassium less than 2.9mEq/L, Call MD/NP
o	Serum potassium 3.0 to 3.5mEq/L, give 40mEq KCL IV and 40mEq KCL PO and notify MD/NP
o	Serum potassium 3.6 to 3.9mEq/L, give 40mEq KCL IV or PO
o	Serum potassium 4 mEq/L or greater, do not give potassium replacement
		  	potassium chloride 20 mEq in 100 mL IVPB (FOR CENTRAL LINE ONLY)	Dose: 20 mEq	Route: intravenous	every 1 hour prn over 60 Minutes for 2 doses	Start: S				  	potassium chloride (KLOR-CON) packet 40 mEq	Dose: 40 mEq	Route: oral	once PRN	Start: S			Instructions:	Dissolve contents of each packet in 4 oz. of water or other beverage.			Electrolyte Replacement
  	TREATMENT CONDITIONS 40 	Interval: --	Occurrences: --	Comments:	Magnesium (Normal range 1.6 to 2.6mEq/L)
o	Serum Magnesium less than 1.1mEq/L, Call MD/NP
o	Serum Magnesium 1.2 to 1.5mEq/L, give 4 gram magnesium sulfate IV 
o	Serum Magnesium 1.6 to 1.9mEq/L, give 2 gram magnesium sulfate IV
o	Serum Magnesium 2 mEq/L or greater, do not give magnesium replacement
		  	magnesium sulfate 2 g/50 mL IVPB (premix)	Dose: 2 g	Route: intravenous	once PRN @ 25 mL/hr over 1 Hours	Start: S				  	magnesium sulfate 4 g IVPB (premix)	Dose: 4 g	Route: intravenous	once PRN over 2 Hours	Start: S						Day 10	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Day 11	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Days 12,13,14	Perform every 1 day x3		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Day 15	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Days 16,17	Perform every 1 day x2		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Day 18	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Days 19,20,21	Perform every 1 day x3		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Day 22	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Days 23,24	Perform every 1 day x2		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Day 25	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Days 26,27,28	Perform every 1 day x3		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Day 29	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Days 30,31	Perform every 1 day x2		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Day 32	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Days 33,34,35	Perform every 1 day x3		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes					Day 36	Perform every 1 day x1		Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --		☑	ECG 12-LEAD	Interval: Once	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 67	Interval: Once	Occurrences: --	Comments:	Supplement to maintain magnesium GREATER than 2 and potassium GREATER than 4.

Refer to Potassium Replacement Scale.
			Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Pre-Medications
  	ondansetron (ZOFRAN) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	arsenic trioxide (TRISENOX) 0.15 mg/kg in sodium chloride 0.9% 250 mL chemo IVPB	Dose: 0.15 mg/kg	Route: intravenous	once over 2 Hours for 1 dose			Offset: 30 Minutes	Instructions:	This drug requires close monitoring of electrolytes.  Check electrolytes twice weekly and supplement to keep magnesium greater than 2 and potassium greater than 4.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	ARSENIC TRIOXIDE 1 MG/ML INTRAVENOUS SOLUTION	Medications	0.15 mg/kg	Main Ingredient	Yes	SODIUM CHLORIDE 0.9 % INTRAVENOUS SOLUTION	QS Base	250 mL	Yes	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	QS Base	250 mL	No	Yes