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OP RSH PRO00038031 ABDELRAHIM PHASE 1 5FU_HT SCREENING	

Types:      Research Oncology Treatment
Synonyms:  5FU, HT, HYDROXYTYROSOL, COLORECTAL , METASTATIC , ADVANCED

Screening	Repeat 1 time	Cycle length: 28 days	Screening	Perform every 1 day x1			Research tolerance: -0/+0 days	Nursing Orders
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	After consenting, patients must meet all the following INCLUSION criteria: 
1. Histopathologically or cytologically confirmed advanced or metastatic CRC
2. Patient is eligible for first-line of therapy for advanced or metastatic CRC, such as 5FU-based therapy.
3. Life expectancy greater than or equal to 6 months
			Nursing Orders
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	After consenting, patients must NOT meet any of the following EXCLUSION criteria: 
1. Hematology laboratory values of: a. Absolute neutrophil count of LESS THAN OR EQUAL TO 1500 cells/mm3; Platelets LESS THAN OR EQUAL TO 100,000 cells/MM3; Hemoglobin LESS THAN OR EQUAL TO 9 g/dl; 
2. Hepatic laboratory values of asparate transaminase or alanine amiotranferase: GREATER THAN 5 x upper limits of normal (ULN) if the documented history of hepatic metastases; or GREATER THAN 2.5 x ULN if no liver metastases are present; 
3. Serum albumin LESS THAN 2.8 g/dl;  
4. Total bilirubin GREATER THAN 1.5 x ULN or GREATER THAN 1.5 mg/dl;    
5. Prothrombin time (PT) or international normalized ratio (INR) GREATER THAN 1.5 x ULN; 
6. Estimated glomerular filtration rate <50 ml/min; 
7. Positive pregnancy test
			Nursing Orders
  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Physical exam
includes Blood pressure, pulse ox, oral temperature, respiratory rate, height and weight.
			Nursing Orders
  	ONC NURSING COMMUNICATION 62	Interval: --	Occurrences: --	Comments:	ECOG status
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --			Procedures
  	BIOPSY	Interval: --	Occurrences: --	Comments:	Tissue biopsy (optional)
			Nursing Orders
  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Collection of archival tissue if available
			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Concomitant Medication review
				Baseline: -7 to 0 day	Perform every 1 day x1			Research tolerance: -0/+0 days	Nursing Orders
  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Physical exam
includes Blood pressure, pulse ox, oral temperature, respiratory rate, height and weight.
			Nursing Orders
  	ONC NURSING COMMUNICATION 62	Interval: --	Occurrences: --	Comments:	ECOG status
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --			Labs
  	CARCINOEMBRYONIC ANTIGEN (CEA)	Interval: --	Occurrences: --			Imaging
  	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION	Interval: --	Occurrences: --	Comments:	Adverse events review
			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Concomitant Medication review