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RESEARCH PRO17598 NIRAVATH OBESITY STUDY ARM 1	

Types:      Research Oncology Treatment
Synonyms:  PRO00017598, 17598, NIRAVATH, LETROZOLE, AROMATASE, OBESE, POST MENOPAUSAL WOMEN , BREAST CANCER

Baseline/ Screening: (Up to 2 weeks prior to randomization and drug dispense)	Repeat 1 time	Cycle length: 14 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Complete physical exam.
		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Blood Pressure, heart rate, respiratory rate, and oral temperature.
		  	HEIGHT AND WEIGHT	Interval: --	Occurrences: --		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Calculate body surface area (BSA).
		  	ONC NURSING COMMUNICATION 4	Interval: --	Occurrences: --	Comments:	ECOG Performance status.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --					
Intervention Period (Minimum 21 days up to 30 days of active exposure to Treatment)	Repeat 1 time	Cycle length: 30 days	Day 1	Perform every 1 day x1		Nursing Orders
  	CLINIC APPOINTMENT REQUEST	Interval: --	Occurrences: --		  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Complete physical exam.
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Review of Symptoms.
		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Blood Pressure, heart rate, respiratory rate, and oral temperature.
		  	HEIGHT AND WEIGHT	Interval: --	Occurrences: --		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Calculate body surface area (BSA).
		  	ONC NURSING COMMUNICATION 4	Interval: --	Occurrences: --	Comments:	ECOG Performance status.
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Arm1: Letrozole 2.5 mg by mouth daily.
(Minimum 21 days up to 30 days of active exposure to Treatment)
Research Coordinator - Please obtain Rx from IDS Pharmacy
					
End of Treatment	Repeat 1 time	Cycle length: 1 day	Day 1	Perform every 1 day x1		Nursing Orders
  	CLINIC APPOINTMENT REQUEST	Interval: --	Occurrences: --		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Review of Symptoms.
		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Blood Pressure, heart rate, respiratory rate, and oral temperature.
		  	HEIGHT AND WEIGHT	Interval: --	Occurrences: --		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Calculate body surface area (BSA).
		  	ONC NURSING COMMUNICATION 4	Interval: --	Occurrences: --	Comments:	ECOG Performance status.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --					
Surgery	Repeat 1 time	Cycle length: 1 day	Day 1	Perform every 1 day x1		Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Schedule subject for surgery to obtain tumor tissue sampling.
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --