If this file opens in Compatibility Mode using Microsoft Word, convert to the latest document format to avoid potential formatting issues.	

RESEARCH PRO17580 DARCOURT - SGN22E-001	

Types:      Research Oncology Treatment
Synonyms:  PRO00017580, DARCOURT, ENFORTUMAB, VEDOTIN

Screening	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
☑	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
☑	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --		☑	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --		☑	HEPATITIS B SURFACE ANTIGEN	Interval: --	Occurrences: --		☑	HEPATITIS B VIRUS DNA, QUANTITATIVE, REAL-TIME PCR (WITH LABCORP SERIAL MONITORING)	Interval: --	Occurrences: --		☑	HEPATITIS B CORE ANTIBODY IGM	Interval: --	Occurrences: --		☑	HEPATITIS C ANTIBODY	Interval: --	Occurrences: --		☑	HEPATITIS C VIRUS (HCV), QUANTITATIVE PCR	Interval: --	Occurrences: --			Imaging
☑	CT HEAD W WO CONTRAST	Interval: --	Occurrences: --		☑	CT HEAD W CONTRAST	Interval: --	Occurrences: --		☑	CT HEAD WO CONTRAST	Interval: --	Occurrences: --		☑	MRI BRAIN W WO CONTRAST	Interval: --	Occurrences: --		☑	MRI BRAIN W CONTRAST	Interval: --	Occurrences: --		☑	MRI BRAIN WO CONTRAST	Interval: --	Occurrences: --		☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --		☑	MRI CHEST W CONTRAST	Interval: --	Occurrences: --		☑	ZZZABDOMEN W CONTRAST	Interval: --	Occurrences: --		☑	MRI PELVIS W CONTRAST	Interval: --	Occurrences: --		☑	NM BONE SCAN WHOLE BODY	Interval: --	Occurrences: --			Nursing Orders
☑	EYE EXAM	Interval: --	Occurrences: --	Comments:	Complete/Slit Lamp Eye Exam
			Labs
☑	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 100	Interval: --	Occurrences: --	Comments:	Collect Medical History
		  	ONC NURSING COMMUNICATION 102	Interval: --	Occurrences: --	Comments:	Complete Eye examination
		  	ONC NURSING COMMUNICATION 103	Interval: --	Occurrences: --	Comments:	Review study consent form
					
Baseline	Repeat 1 time	Cycle length: 7 days	Day 1	Perform every 1 day x1		Nursing Orders
☑	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: --	Occurrences: --		☑	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		☑	URIC ACID LEVEL	Interval: --	Occurrences: --		☑	LDH	Interval: --	Occurrences: --		☑	AMYLASE LEVEL	Interval: --	Occurrences: --		☑	LIPASE LEVEL	Interval: --	Occurrences: --		☑	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	Either serum OR urine pregnancy test for females of childbearing potential.
		☑	HCG QUANTITATIVE, SERUM	Interval: --	Occurrences: --	Comments:	Either serum OR urine pregnancy test for females of childbearing potential.
		☑	HCG QUALITATIVE, URINE SCREEN	Interval: --	Occurrences: --	Comments:	Either serum OR urine pregnancy test for females of childbearing potential.
		☑	CREATININE CLEARANCE, URINE, 24 HOUR	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
		  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature)
		  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Height - Must be measured by provider (Patient cannot state)
		  	ONC NURSING COMMUNICATION 11	Interval: --	Occurrences: --	Comments:	Weight - Must be measured by provider (Patient cannot state)
		  	ECG 12-LEAD	Interval: --	Occurrences: --	Comments:	Study staff to perform (patient must be in supine position for 5 minutes and to be done prior to obtaining PK and biomarker samples if possible)
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Physical exam must be performed on this date
					
Cycle 1	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
☑	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: --	Occurrences: --		☑	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		☑	URIC ACID LEVEL	Interval: --	Occurrences: --		☑	LDH	Interval: --	Occurrences: --		☑	AMYLASE LEVEL	Interval: --	Occurrences: --		☑	LIPASE LEVEL	Interval: --	Occurrences: --		☑	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	Either serum or urine pregnancy test
		☑	HCG QUANTITATIVE, SERUM	Interval: --	Occurrences: --	Comments:	Either serum or urine pregnancy test
		☑	HCG QUALITATIVE, URINE SCREEN	Interval: --	Occurrences: --	Comments:	Either urine or serum pregnancy test
			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
		  	ONC NURSING COMMUNICATION 14	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature, weight)
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Physical exam must be performed on this date
		  	ONC NURSING COMMUNICATION 15	Interval: --	Occurrences: --	Comments:	QLQ-C30 Questionnaire
		  	ONC NURSING COMMUNICATION 16	Interval: --	Occurrences: --	Comments:	EQ-5D Questionnaire
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	For ATA Assessments
		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	For Plasma Biomarker Sampling
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	Pre-Dose PK Sampling
			Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	Post-Dose PK Sampling
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 8	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	AMYLASE LEVEL	Interval: --	Occurrences: --		  	LIPASE LEVEL	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature)
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 15	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	AMYLASE LEVEL	Interval: --	Occurrences: --		  	LIPASE LEVEL	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature)
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 22	Perform every 1 day x1				
Cycle 2	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
☑	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: --	Occurrences: --		☑	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		☑	URIC ACID LEVEL	Interval: --	Occurrences: --		☑	LDH	Interval: --	Occurrences: --		☑	AMYLASE LEVEL	Interval: --	Occurrences: --		☑	LIPASE LEVEL	Interval: --	Occurrences: --		☑	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	Either serum or urine pregnancy test
		☑	HCG QUANTITATIVE, SERUM	Interval: --	Occurrences: --	Comments:	Either serum or urine pregnancy test
		☑	HCG QUALITATIVE, URINE SCREEN	Interval: --	Occurrences: --	Comments:	Either urine or serum pregnancy test
			Imaging
☑	CT HEAD W WO CONTRAST	Interval: --	Occurrences: --		☑	CT HEAD W CONTRAST	Interval: --	Occurrences: --		☑	CT HEAD WO CONTRAST	Interval: --	Occurrences: --		☑	MRI BRAIN W WO CONTRAST	Interval: --	Occurrences: --		☑	MRI BRAIN W CONTRAST	Interval: --	Occurrences: --		☑	MRI BRAIN WO CONTRAST	Interval: --	Occurrences: --		☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --		☑	MRI CHEST W CONTRAST	Interval: --	Occurrences: --		☑	ZZZABDOMEN W CONTRAST	Interval: --	Occurrences: --		☑	MRI PELVIS W CONTRAST	Interval: --	Occurrences: --		☑	NM BONE SCAN WHOLE BODY	Interval: --	Occurrences: --			Nursing Orders
☑	EYE EXAM	Interval: --	Occurrences: --	Comments:	Complete Eye / Slit Lamp Eye Exam as clinically indicated
			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
		  	ONC NURSING COMMUNICATION 14	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature, weight)
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Physical exam must be performed on this date
		  	ONC NURSING COMMUNICATION 15	Interval: --	Occurrences: --	Comments:	QLQ-C30 Questionnaire
		  	ONC NURSING COMMUNICATION 16	Interval: --	Occurrences: --	Comments:	EQ-5D Questionnaire
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	For ATA Assessments
		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	For Plasma Biomarker Sampling
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	Pre-Dose PK Sampling
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	Post-Dose PK Sampling
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 8	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	AMYLASE LEVEL	Interval: --	Occurrences: --		  	LIPASE LEVEL	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature)
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 15	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	AMYLASE LEVEL	Interval: --	Occurrences: --		  	LIPASE LEVEL	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature)
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 22	Perform every 1 day x1				
Cycle 3	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
☑	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: --	Occurrences: --		☑	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		☑	URIC ACID LEVEL	Interval: --	Occurrences: --		☑	LDH	Interval: --	Occurrences: --		☑	AMYLASE LEVEL	Interval: --	Occurrences: --		☑	LIPASE LEVEL	Interval: --	Occurrences: --		☑	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	Either serum or urine pregnancy test
		☑	HCG QUANTITATIVE, SERUM	Interval: --	Occurrences: --	Comments:	Either serum or urine pregnancy test
		☑	HCG QUALITATIVE, URINE SCREEN	Interval: --	Occurrences: --	Comments:	Either urine or serum pregnancy test
			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
		  	ONC NURSING COMMUNICATION 14	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature, weight)
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Physical exam must be performed on this date
		  	ONC NURSING COMMUNICATION 15	Interval: --	Occurrences: --	Comments:	QLQ-C30 Questionnaire
		  	ONC NURSING COMMUNICATION 16	Interval: --	Occurrences: --	Comments:	EQ-5D Questionnaire
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	For ATA Assessments
		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	For Plasma Biomarker Sampling
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	Pre-Dose PK Sampling
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	Post-Dose PK Sampling
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 8	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	AMYLASE LEVEL	Interval: --	Occurrences: --		  	LIPASE LEVEL	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature)
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 15	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	AMYLASE LEVEL	Interval: --	Occurrences: --		  	LIPASE LEVEL	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature)
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 22	Perform every 1 day x1				
Cycle 4	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
☑	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: --	Occurrences: --		☑	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		☑	URIC ACID LEVEL	Interval: --	Occurrences: --		☑	LDH	Interval: --	Occurrences: --		☑	AMYLASE LEVEL	Interval: --	Occurrences: --		☑	LIPASE LEVEL	Interval: --	Occurrences: --		☑	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	Either serum or urine pregnancy test
		☑	HCG QUANTITATIVE, SERUM	Interval: --	Occurrences: --	Comments:	Either serum or urine pregnancy test
		☑	HCG QUALITATIVE, URINE SCREEN	Interval: --	Occurrences: --	Comments:	Either urine or serum pregnancy test
			Imaging
☑	CT HEAD W WO CONTRAST	Interval: --	Occurrences: --		☑	CT HEAD W CONTRAST	Interval: --	Occurrences: --		☑	CT HEAD WO CONTRAST	Interval: --	Occurrences: --		☑	MRI BRAIN W WO CONTRAST	Interval: --	Occurrences: --		☑	MRI BRAIN W CONTRAST	Interval: --	Occurrences: --		☑	MRI BRAIN WO CONTRAST	Interval: --	Occurrences: --		☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --		☑	MRI CHEST W CONTRAST	Interval: --	Occurrences: --		☑	ZZZABDOMEN W CONTRAST	Interval: --	Occurrences: --		☑	MRI PELVIS W CONTRAST	Interval: --	Occurrences: --		☑	NM BONE SCAN WHOLE BODY	Interval: --	Occurrences: --			Nursing Orders
☑	EYE EXAM	Interval: --	Occurrences: --	Comments:	Complete Eye / Slit Lamp Eye Exam as clinically indicated
			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
		  	ONC NURSING COMMUNICATION 14	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature, weight)
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Physical exam must be performed on this date
		  	ONC NURSING COMMUNICATION 15	Interval: --	Occurrences: --	Comments:	QLQ-C30 Questionnaire
		  	ONC NURSING COMMUNICATION 16	Interval: --	Occurrences: --	Comments:	EQ-5D Questionnaire
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	For ATA Assessments
		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	For Plasma Biomarker Sampling
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	Pre-Dose PK Sampling
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Pharmacokinetic Instructions
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --	Comments:	Post-Dose PK Sampling
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 8	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	AMYLASE LEVEL	Interval: --	Occurrences: --		  	LIPASE LEVEL	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature)
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 15	Perform every 1 day x1		Appointment Requests
  	ONC INFUSION APPOINTMENT REQUEST 6	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	AMYLASE LEVEL	Interval: --	Occurrences: --		  	LIPASE LEVEL	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify CBC with differential as follow.
o white blood cell count with five-part differential (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) 
o hemoglobin is GREATER THAN or EQUAL TO 9 g/dL
o hematocrit 
o ANC is GREATER THAN or EQUAL TO 1.0 x 109 / L. 
o Platelets is GREATER THAN or EQUAL TO 100 x 109 / L.
o AST and ALT is LESS THAN or EQUAL TO 3.0 × upper limit of normal (ULN). 
o Serum bilirubin is LESS THAN or EQUAL TO 1.5 × upper limit of normal (ULN) or LESS THAN or EQUAL TO 3 X ULN for patients with Gilbert's disease. 
o CrCl is GREATER THAN or EQUAL TO 30 mL/min estimated by Cockcroft-Gault criteria
		  	ONC NURSING COMMUNICATION 80	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs (CMP) using institution reference range.
o Sodium
o Potassium
o Chloride
o CO2
o Anion gap
o BUN
o Creatinine
o Glucose
o Calcium
o Protein
o Albumin
o A/G ratio
o Alkaline phosphatase
o AST
o ALT
o Total bilirubin
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Prior to treatment, verify the following labs using institution reference range.
o Lactate Dehydrogenase (LDH)
o Phosphorus
o Amylase
o Lipase
o Uric Acid
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature)
			Pre-Medications
☑	acetaminophen (TYLENOL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) tablet	Dose: --	Route: oral	once for 1 dose	Start: S				☑	diphenhydrAMINE (BENADRYL) injection	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☑	dexAMETHasone (DECADRON) tablet 4 mg	Dose: 4 mg	Route: oral	once for 1 dose	Start: S					Chemotherapy
  	INV-enfortumab vedotin (SGN22E-001/Pro00017580/Darcourt) 1.25 mg/kg in dextrose 5% 0 mL infusion	Dose: 1.25 mg/kg	Route: intravenous	once over 30 Minutes for 1 dose			Offset: 1 Hours	Instructions:	Prepared bag contains active enfortumab vedotin. Administer intravenously using 0.2 micron in line filter over 30 minutes. Infuse within 6 hours of preparation, kept at room temperature.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	INV-ENFORTUMAB VEDOTIN 30 MG INJECTION SOLN (SGN22E-001/PRO00017580/DARCOURT)	Medications	1.25 mg/kg	Main Ingredient	Yes	DEXTROSE 5 % IN WATER (D5W) INTRAVENOUS SOLUTION	Base	 	Always	Yes				Nursing Orders
  	ONC NURSING COMMUNICATION 75	Interval: --	Occurrences: --	Comments:	Extravasation of enfortumab vedotin may be associated with skin and soft tissue injury. Therefore, precautions should be taken to prevent extravasation. Patients and the infusion site should be monitored closely throughout the infusion. Events of extravasation should be managed per institutional guidelines.
			Discharge Nursing Orders
  	ONC NURSING COMMUNICATION 76	Interval: --	Occurrences: --	Comments:	Discontinue IV.
			Discharge Nursing Orders
☑	sodium chloride 0.9 % flush 20 mL	Dose: 20 mL	Route: intravenous	PRN					☑	HEParin, porcine (PF) injection 500 Units	Dose: 500 Units	Route: intra-catheter	once PRN	Start: S			Instructions:	Concentration: 100 units/mL. Heparin flush for Implanted Vascular Access Device maintenance.				Day 22	Perform every 1 day x1				
Cycle 5	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1			Day 8	Perform every 1 day x1			Day 15	Perform every 1 day x1			Day 22	Perform every 1 day x1				
Cycle 6	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1			Day 8	Perform every 1 day x1			Day 15	Perform every 1 day x1			Day 22	Perform every 1 day x1				
End of Treatment	Repeat 1 time	Cycle length: 56 days	Day 1	Perform every 1 day x1		Nursing Orders
☑	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Venipuncture
			Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: --	Occurrences: --		☑	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		☑	URIC ACID LEVEL	Interval: --	Occurrences: --		☑	LDH	Interval: --	Occurrences: --		☑	AMYLASE LEVEL	Interval: --	Occurrences: --		☑	LIPASE LEVEL	Interval: --	Occurrences: --		☑	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	Either serum OR urine pregnancy test
		☑	HCG QUANTITATIVE, SERUM	Interval: --	Occurrences: --	Comments:	Either serum OR urine pregnancy test
		☑	HCG QUALITATIVE, URINE SCREEN	Interval: --	Occurrences: --	Comments:	Either serum OR urine pregnancy test
			Imaging
☑	CT HEAD W WO CONTRAST	Interval: --	Occurrences: --	Comments:	As clinically indicated
		☑	CT HEAD W CONTRAST	Interval: --	Occurrences: --	Comments:	As clinically indicated
		☑	CT HEAD WO CONTRAST	Interval: --	Occurrences: --	Comments:	As clinically indicated
		☑	MRI BRAIN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	As clinically indicated
		☑	MRI BRAIN W CONTRAST	Interval: --	Occurrences: --	Comments:	As clinically indicated
		☑	MRI BRAIN WO CONTRAST	Interval: --	Occurrences: --	Comments:	As clinically indicated
		☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	Not required if conducted LESS THAN 4 weeks prior to EOT
		☑	MRI CHEST W CONTRAST	Interval: --	Occurrences: --	Comments:	Not required if conducted LESS THAN 4 weeks prior to EOT
		☑	ZZZABDOMEN W CONTRAST	Interval: --	Occurrences: --	Comments:	Not required if conducted LESS THAN 4 weeks prior to EOT
		☑	MRI PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	Not required if conducted LESS THAN 4 weeks prior to EOT
		☑	NM BONE SCAN WHOLE BODY	Interval: --	Occurrences: --	Comments:	As clinically indicated
			Nursing Orders
☑	EYE EXAM	Interval: --	Occurrences: --	Comments:	Complete Eye / Slit Lamp Eye Exam as clinically indicated
		☑	ECG 12-LEAD	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
		  	ONC NURSING COMMUNICATION 14	Interval: --	Occurrences: --	Comments:	Vital signs  (blood pressure, heart rate, respiratory rate, temperature, weight)
		  	ECG 12-LEAD	Interval: --	Occurrences: --	Comments:	Study staff to perform (Contact CCAT at 713-441-9984)
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Physical exam must be performed on this date
		  	ONC NURSING COMMUNICATION 20	Interval: --	Occurrences: --	Comments:	Brain Scan -only if clinically indicated or present at baseline
		  	ONC NURSING COMMUNICATION 22	Interval: --	Occurrences: --	Comments:	Bone Scan-only if clinically indicated or present at baseline
		  	EYE EXAM	Interval: --	Occurrences: --	Comments:	Slit lamp eye examination (on the first 60 enrolled patients or patients who experience corneal adverse events during the study and must be performed > 4 weeks from last dose).
					
Follow up for first 12 months	Repeat 12 times	Cycle length: 56 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Physical exam must be performed on this date
		  	ONC NURSING COMMUNICATION 20	Interval: --	Occurrences: --	Comments:	Brain Scan -only if clinically indicated or present at baseline
		  	ONC NURSING COMMUNICATION 22	Interval: --	Occurrences: --	Comments:	Bone Scan-only if clinically indicated or present at baseline
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
		  	ONC NURSING COMMUNICATION 25	Interval: --	Occurrences: --	Comments:	Survival Status
					
Follow up after first 12 months	Repeat 12 times	Cycle length: 84 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Physical exam must be performed on this date
		  	ONC NURSING COMMUNICATION 20	Interval: --	Occurrences: --	Comments:	Brain Scan -only if clinically indicated or present at baseline
		  	ONC NURSING COMMUNICATION 22	Interval: --	Occurrences: --	Comments:	Bone Scan-only if clinically indicated or present at baseline
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	ECOG Performance Status
		  	ONC NURSING COMMUNICATION 25	Interval: --	Occurrences: --	Comments:	Survival Status