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OP RESEARCH PRO00026882 JAIN A221602	

Types:      Research Oncology Treatment, ONCOLOGY SUPPORTIVE CARE
Synonyms:  26882, PRO26882, ZYPREXA, OLANZAPINE, FOSAPREPITANT, EMEND, NAUSEA, VOMITING, PREVENTION, CINV, HEC

Screening	Repeat 1 time	Cycle length: 28 days	28 Days Before Registration	Perform every 1 day x1		Nursing Orders
  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	To be completed LESS than or EQUAL to 28 DAYS before registration.
		  	RESEARCH - VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --		  	RESEARCH - HEIGHT AND WEIGHT	Interval: --	Occurrences: --		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	ECOG performance status
			Labs
  	CREATININE LEVEL	Interval: --	Occurrences: --		  	AST (SGOT)	Interval: --	Occurrences: --		  	ALT (SGPT)	Interval: --	Occurrences: --		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --				7 Days Before Registration	Perform every 1 day x1		Labs
  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	Only for female of childbearing potential. Must be done LESS than or EUQAL to 7 days prior to registration.
					
Cycle 1	Repeat 1 time	Cycle length: 21 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Baseline Nausea and Vomiting Questionnaire. To be completed using ePRO.
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Euro QOL(EQ-5D-3L) Questionnaire. To be completed using ePRO.
			Antiemetics
☑	ONC PROVIDER COMMUNICATION	Interval: --	Occurrences: --	Comments:	o Rght click to add Palonosetron 0.25 mg OR Ondansetron 8-16 mg IV OR Ondansetron 16-24 mg PO
o Only be given on Day 1 of chemotherapy.
		☐	palonosetron (ALOXI) injection 0.25 mg	Dose: 0.25 mg	Route: intravenous	once for 1 dose	Start: S				☐	ondansetron (ZOFRAN) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☐	ondansetron (ZOFRAN) tablet	Dose: --	Route: oral	once for 1 dose	Start: S					Antiemetics
  	dexamethasone (DECADRON) tablet 12 mg	Dose: 12 mg	Route: oral	once for 1 dose	Start: S					Antiemetics
  	ONC PROVIDER COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	IDS Pharmacy will enter orders for Fosaprepitant/Placebo orders.
			Antiemetics
  	ONC PROVIDER COMMUNICATION 3	Interval: --	Occurrences: --	Comments:	IDS Pharmacy will supply Olanzapine per paper order.
		  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Olanzapine on the day of chemotherapy (day 1) may be taken prior to chemotherapy or at bedtime (after chemotherapy).
				Days 2,3,4	Perform every 1 day x3		Nursing Orders
  	ONC NURSING COMMUNICATION 11	Interval: --	Occurrences: --	Comments:	Phone call to assess adverse events
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Nausea and Vomiting Daily Questionnaire
		  	ONC NURSING COMMUNICATION 14	Interval: --	Occurrences: --	Comments:	Euro QOL(EQ-5D-3L) Questionnaire
			Antiemetics
  	dexamethasone (DECADRON) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Antiemetics
  	ONC PROVIDER COMMUNICATION 3	Interval: --	Occurrences: --	Comments:	IDS Pharmacy will supply Olanzapine per paper order.
				Days 5,6	Perform every 1 day x2		Nursing Orders
  	ONC NURSING COMMUNICATION 11	Interval: --	Occurrences: --	Comments:	Phone call to assess adverse events
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Nausea and Vomiting Daily Questionnaire
		  	ONC NURSING COMMUNICATION 14	Interval: --	Occurrences: --	Comments:	Euro QOL(EQ-5D-3L) Questionnaire
					
Cycles 2 to 4	Repeat 3 times	Cycle length: 21 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ONC NURSING COMMUNICATION 15	Interval: --	Occurrences: --	Comments:	Nausea and Vomiting Questionnaire. To be completed using ePRO.
		  	ONC NURSING COMMUNICATION 16	Interval: --	Occurrences: --	Comments:	Euro QOL(EQ-5D-3L) Questionnaire. To be completed using ePRO.
			Antiemetics
☑	ONC PROVIDER COMMUNICATION	Interval: --	Occurrences: --	Comments:	o Rght click to add Palonosetron 0.25 mg OR Ondansetron 8-16 mg IV OR Ondansetron 16-24 mg PO
o Only be given on Day 1 of chemotherapy.
		☐	palonosetron (ALOXI) injection 0.25 mg	Dose: 0.25 mg	Route: intravenous	once for 1 dose	Start: S				☐	ondansetron (ZOFRAN) IV	Dose: --	Route: intravenous	once for 1 dose	Start: S				☐	ondansetron (ZOFRAN) tablet	Dose: --	Route: oral	once for 1 dose	Start: S					Antiemetics
  	dexamethasone (DECADRON) tablet 12 mg	Dose: 12 mg	Route: oral	once for 1 dose	Start: S					Antiemetics
  	fosaprepitant (EMEND) IVPB 150 mg	Dose: 150 mg	Route: intravenous	once over 30 Minutes for 1 dose	Start: S					Antiemetics
  	ONC PROVIDER COMMUNICATION 3	Interval: --	Occurrences: --	Comments:	IDS Pharmacy will supply Olanzapine per paper order.
		  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Olanzapine on the day of chemotherapy (day 1) may be taken prior to chemotherapy or at bedtime (after chemotherapy).
				Days 2,3,4	Perform every 1 day x3		Nursing Orders
  	ONC NURSING COMMUNICATION 11	Interval: --	Occurrences: --	Comments:	Phone call to assess adverse events
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Nausea and Vomiting Daily Questionnaire
		  	ONC NURSING COMMUNICATION 14	Interval: --	Occurrences: --	Comments:	Euro QOL(EQ-5D-3L) Questionnaire
			Antiemetics
  	dexamethasone (DECADRON) tablet 8 mg	Dose: 8 mg	Route: oral	once for 1 dose	Start: S					Antiemetics
  	ONC PROVIDER COMMUNICATION 3	Interval: --	Occurrences: --	Comments:	IDS Pharmacy will supply Olanzapine per paper order.
				Days 5,6	Perform every 1 day x2		Nursing Orders
  	ONC NURSING COMMUNICATION 11	Interval: --	Occurrences: --	Comments:	Phone call to assess adverse events
		  	ONC NURSING COMMUNICATION 12	Interval: --	Occurrences: --	Comments:	Nausea and Vomiting Daily Questionnaire
		  	ONC NURSING COMMUNICATION 14	Interval: --	Occurrences: --	Comments:	Euro QOL(EQ-5D-3L) Questionnaire