PATISIRAN (ONPATTRO) INFUSION		version 2/27/2025		

Appointment Requests 	

	
	Interval	Defer Until	Duration	
	☑	Referral to IV Infusion Room	Every 3 weeks	S	 treatments	
		Status: Future, Expected: S, Expires: S+365, Clinic Performed
	Urgency of Scheduling: Routine		

Nursing Orders 	

	
	Interval	Defer Until	Duration	
	☐	Insert Peripheral IV or Access Portacath	Every visit	S	Until discont'd	
		No details available for preview		
	☐	Vital signs - T/P/R/BP	Every visit	S	Until discont'd	
		Clinic Performed, Normal		
	☐	sodium chloride 0.9% flush 10 mL	Every visit	S	Until discont'd	
		10 mL, intravenous, PRN, line care, Starting when released, for 10 doses		
	☐	sodium chloride 0.9% infusion 250 mL	Every visit	S	Until discont'd	
		250 mL, intravenous, at 30 mL/hr, PRN, Flush Bag, Starting when released, Until Discontinued		
	☐	HEParin, porcine injection 500 Units	Every visit	S	Until discont'd	
		500 Units, intra-catheter, once, Starting when released
	ONLY IF PATIENT HAS PORTACATH: Flush portacath before removing needle from portacath.		
	☐	Nursing communication	Every visit	S	Until discont'd	
		Monitor patient for signs of infusion reaction. If patient has infusion reaction, stop infusion, notify physician, and administer emergency medications as ordered Every visit Until discont'd Details		
	☐	Discontinue IV	Every visit	S	Until discont'd	
		No details available for preview		

Pre-Medications 	

	
	Interval	Defer Until	Duration	
	☐	acetaminophen (TYLENOL) tablet 650 mg	Every visit	S	Until discont'd	
		650 mg, oral, once, Starting when released
	Maximum of 4 grams of acetaminophen per day from all sources. (Cirrhosis patients maximum: 2 grams per day from all sources).		
	☐	diphenhydrAMINE (BENADRYL) injection 50 mg	Every visit	S	Until discont'd	
		50 mg, intravenous, once, Starting when released		
	☐	famotidine (PEPCID) injection 20 mg	Every visit	S	Until discont'd	
		20 mg, intravenous, once, Starting when released		
	☐	dexAMETHasone (DECADRON) IV 10 mg	Every visit	S	Until discont'd	
		10 mg, intravenous, once, Starting when released		

Medications 	

	
	Interval	Defer Until	Duration	
	☐	patisiran (lipid complex) (ONPATTRO) 30 mg in sodium chloride 0.9% 200 mL IVPB (RESTRICTED)	Every 3 weeks	S	Until discont'd	
		30 mg, intravenous, once, Starting 30 minutes after treatment start time
	For patients GREATER than or EQUAL to 100 Kg.
	Initial infusion rate of 1 mL/minute for 15 minutes, then increase to ~3 mL/minute for the remainder of the infusion. 
	Use a dedicated line with an infusion set containing a 1.2 micron PES in-line infusion filter. Use DEHP-free infusion sets and lines.
	Administer only through a free-flowing venous access line. Monitor the infusion site for infiltration. Manage extravasation according to local standard practice for non-vesicants.		
	☐	patisiran (lipid complex) (ONPATTRO) 0.3 mg/kg in sodium chloride 0.9% 200 mL IVPB	Every 3 weeks	S	Until discont'd	
		0.3 mg/kg, intravenous, once, Starting 30 minutes after treatment start time
	For patients LESS than 100 Kg 
	Initial infusion rate of 1 mL/minute for 15 minutes, then increase to ~3 mL/minute for the remainder of the infusion. 
	Use a dedicated line with an infusion set containing a 1.2 micron PES in-line infusion filter. Use DEHP-free infusion sets and lines.
	Administer only through a free-flowing venous access line. Monitor the infusion site for infiltration. Manage extravasation according to local standard practice for non-vesicants.		

Hypersensitivity 	

	
	Interval	Defer Until	Duration	
	☐	acetaminophen (TYLENOL) tablet 650 mg	PRN	S	Until discont'd	
		650 mg, oral, every 4 hours PRN, mild pain (score 1-3), Starting when released, Until Discontinued
	Maximum of 4 grams of acetaminophen per day from all sources. (Cirrhosis patients maximum: 2 grams per day from all sources).		
	☐	diphenhydrAMINE (BENADRYL) tablet 25 mg	PRN	S	Until discont'd	
		25 mg, oral, every 6 hours PRN, itching, Starting when released, Until Discontinued		
	☐	diphenhydrAMINE (BENADRYL) injection 25 mg	PRN	S	Until discont'd	
		25 mg, intravenous, once PRN, for minor infusion reaction, Starting when released, Until Discontinued		
	☐	diphenhydrAMINE (BENADRYL) injection 50 mg	PRN	S	Until discont'd	
		50 mg, intravenous, once PRN, for severe infusion reaction, Starting when released, Until Discontinued		
	☐	epINEPHrine (ADRENALIN) injection 1 mg/mL 0.5 mg	PRN	S	Until discont'd	
		0.5 mg, subcutaneous, once PRN, anaphylaxis, Starting when released, Until Discontinued		
	☐	hydrocortisone sodium succinate (Solu-CORTEF) injection 100 mg	PRN	S	Until discont'd	
		100 mg, intravenous, once PRN, for infusion reaction, Starting when released, Until Discontinued		
	☐	promethazine (PHENERGAN) tablet 25 mg	PRN	S	Until discont'd	
		25 mg, oral, every 6 hours PRN, nausea, vomiting, Starting when released, Until Discontinued		
	☐	sodium chloride 0.9% infusion 250 mL	PRN	S	Until discont'd	
		250 mL, intravenous, once PRN, for hydration, Starting when released, Until Discontinued