Protocol Index	

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OP RESEARCH PRO00038502 GOG-3097  RAMP-301 KAMAT ARM 1	

Types:      Research Oncology Treatment
Synonyms:  

Cycle 1	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --	Comments:	Per institutional standards and as clinically indicated
		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 2	Interval: --	Occurrences: --	Comments:	Full physical examination (Cycle 1 only)
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Quality of Life Questionnaires: 
EORTC QLQ-C30; 
EORTC QLQ-OV28; 
EQ-5D-5L.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 2	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 3	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Quality of Life Questionnaires: 
EORTC QLQ-C30; 
EORTC QLQ-OV28; 
EQ-5D-5L.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 4	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 5	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Quality of Life Questionnaires: 
EORTC QLQ-C30; 
EORTC QLQ-OV28; 
EQ-5D-5L.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 6	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 7	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 8	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 9	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Quality of Life Questionnaires: 
EORTC QLQ-C30; 
EORTC QLQ-OV28; 
EQ-5D-5L.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 10	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 11	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 12	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 13	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Quality of Life Questionnaires: 
EORTC QLQ-C30; 
EORTC QLQ-OV28; 
EQ-5D-5L.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 14	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 15	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 16	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 17	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Quality of Life Questionnaires: 
EORTC QLQ-C30; 
EORTC QLQ-OV28; 
EQ-5D-5L.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 18	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 19	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 20	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 21	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Quality of Life Questionnaires: 
EORTC QLQ-C30; 
EORTC QLQ-OV28; 
EQ-5D-5L.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 22	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
					
Cycle 23	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)
			Imaging
☑	CT CHEST W CONTRAST ABDOMEN W CONTRAST PELVIS W CONTRAST	Interval: --	Occurrences: --	Comments:	CT or MRI every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI CHEST W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI ABDOMEN W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
		☐	MRI PELVIS W WO CONTRAST	Interval: --	Occurrences: --	Comments:	MRI or CT every 8 weeks from randomization date for 18 Cycles (72 weeks), then every 12 weeks thereafter until disease progression
					
Cycle 24	Repeat 1 time	Cycle length: 28 days	Day 1	Perform every 1 day x1		Nursing Orders
  	ECG 12-LEAD	Interval: --	Occurrences: --		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --	Comments:	Includes blood pressure, temperature, respiratory rate, and pulse
		  	ONC NURSING COMMUNICATION 8	Interval: --	Occurrences: --	Comments:	Focused physical examination
		  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	Adverse event evaluation
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Concomitant Therapy/Procedures
			Nursing Orders
  	ONC NURSING COMMUNICATION 9	Interval: --	Occurrences: --	Comments:	Verify patient is taking: 
INV-Avutometinib 0.8mg capsules 3.2 mg PO Twice weekly x 3 weeks, then 1 week off;
INV-Defactinib 200mg tablets 200 mg PO BID x 3 weeks, then 1 week off.

Ordered via paper Rx order sent to IDS pharmacy.
			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	COMPREHENSIVE METABOLIC PANEL	Interval: --	Occurrences: --		  	LDH	Interval: --	Occurrences: --		  	URIC ACID LEVEL	Interval: --	Occurrences: --		  	PHOSPHORUS LEVEL	Interval: --	Occurrences: --		  	MAGNESIUM LEVEL	Interval: --	Occurrences: --		  	CREATINE KINASE, TOTAL (CPK)	Interval: --	Occurrences: --		  	CANCER ANTIGEN 125	Interval: --	Occurrences: --		  	PROTHROMBIN TIME WITH INR	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	PARTIAL THROMBOPLASTIN TIME (PTT)	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	URINALYSIS, AUTOMATED WITH MICROSCOPY	Interval: --	Occurrences: --	Comments:	As clinically indicated
		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For woman of childbearing potential (serum or urine hCG)
			Imaging
◉	TRANSTHORACIC ECHOCARDIOGRAM COMPLETE W CONT STRAIN 3D IF NEEDED	Interval: --	Occurrences: --	Comments:	ECHO/MUGA (Per institutional standards and as clinically indicated)
		◯	NM RADIONUCLIDE ANGIOGRAPHY (MUGA) RESTING ONLY	Interval: --	Occurrences: --	Comments:	MUGA /ECHO (Per institutional standards and as clinically indicated)