Protocol Index	

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OP RESEARCH H-44843 TETRAVI STUDY	

Types:      Research Oncology Treatment
Synonyms:  H44843, 44843

Cycle 1	Repeat 1 time	Cycle length: 50 days	Pre-Infusion	Perform every 1 day x1		Nursing Orders
  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --		  	RESEARCH - HEIGHT AND WEIGHT	Interval: --	Occurrences: --			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	BASIC METABOLIC PANEL	Interval: --	Occurrences: --		  	ALKALINE PHOSPHATASE	Interval: --	Occurrences: --		  	ALBUMIN LEVEL	Interval: --	Occurrences: --		  	BILIRUBIN, TOTAL AND DIRECT	Interval: --	Occurrences: --		  	ALT (SGPT)	Interval: --	Occurrences: --		  	AST (SGOT)	Interval: --	Occurrences: --		  	ADENOVIRUS BY PCR	Interval: --	Occurrences: --		  	BK VIRUS BY PCR	Interval: --	Occurrences: --		  	CYTOMEGALOVIRUS BY PCR	Interval: --	Occurrences: --		  	EPSTEIN BARR VIRUS (EBV) BY PCR	Interval: --	Occurrences: --		  	JC VIRUS, QUANTITATIVE PCR	Interval: --	Occurrences: --		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For females of child bearing age.
			Labs
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --				Day 0	Perform every 1 day x1		Appointment Requests
  	INFUSION APPOINTMENT REQUEST	Interval: --	Occurrences: --			Nursing Orders
  	ONC NURSING COMMUNICATION 10	Interval: --	Occurrences: --	Comments:	Procedural pain protocol for lab draw.
		  	INSERT PERIPHERAL IV OR ACCESS PORTACATH	Interval: --	Occurrences: --	Comments:	Use with 3-way stopcock and tubing.
		  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --		  	PULSE OXIMETRY	Interval: --	Occurrences: --	Comments:	o To be performed Pre-infusion, during infusion, post infusion, then at 30 and 60 minutes. 
o Monitor continuous pulse oximetry during and at least 30 minutes post-infusion.
			Line Care
  	sodium chloride 0.9% flush 20 mL	Dose: 20 mL	Route: intravenous	PRN	Start: S					Line Care
  	sodium chloride 0.9 % infusion 250 mL	Dose: 250 mL	Route: intravenous	once @ 30 mL/hr for 1 dose	Start: S			Instructions:	To keep vein open.			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	BASIC METABOLIC PANEL	Interval: --	Occurrences: --		  	ADENOVIRUS BY PCR	Interval: --	Occurrences: --		  	BK VIRUS BY PCR	Interval: --	Occurrences: --		  	CYTOMEGALOVIRUS BY PCR	Interval: --	Occurrences: --		  	EPSTEIN BARR VIRUS (EBV) BY PCR	Interval: --	Occurrences: --		  	JC VIRUS, QUANTITATIVE PCR	Interval: --	Occurrences: --		  	HCG QUALITATIVE, SERUM SCREEN	Interval: --	Occurrences: --	Comments:	For females of child bearing age.
			Labs
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --			Pre-Medications
  	ONC NURSING COMMUNICATION 11	Interval: --	Occurrences: --	Comments:	Please order Pre Medications as soon as labs are sent.
		  	acetaminophen (TYLENOL) tablet 5-10 mg/kg (Treatment Plan)	Dose: 5-10 mg/kg	Route: oral	once for 1 dose	Start: S				  	diphenhydrAMINE (BENADRYL) injection 0.25-0.5 mg/kg (Treatment Plan)	Dose: 0.25-0.5 mg/kg	Route: intravenous	once for 1 dose	Start: S					Nursing Orders
  	ONC NURSING COMMUNICATION 5	Interval: --	Occurrences: --	Comments:	o Cells to be administered by physician. 
o Clinic nurse to remain at bedside during the entire infusion.
		  	ONC NURSING COMMUNICATION 6	Interval: --	Occurrences: --	Comments:	Verify cell dose and patient information on Component Infusion Form.
		  	ASSESS	Interval: --	Occurrences: --	Comments:	Assess patient for immediate reactions: 
a. Allergic reactions (anaphylaxis); 
b. Decreased oxygenation (due to migration of lymphocytes to lungs).
			Emergency Medications
  	TRANSFUSION REACTION EVALUATION	Interval: Once	Occurrences: --	Comments:	Emergency Medications - Anaphylactic precautions: 
o Must be at bedside prior to infusion. 
o Oxygen & suction set up, sterile gloves, normal saline flush, 1ml and 3ml syringes w/needles.  
o Keep medications at the bedside to administer per physician's orders.
		  	diphenhydrAMINE (BENADRYL) injection 50 mg	Dose: 50 mg	Route: intravenous	once PRN	Start: S			Instructions:	Keep at the bedside to administer per physician's orders.		  	hydrocortisone sodium succinate (Solu-CORTEF) injection 250 mg	Dose: 250 mg	Route: intravenous	once PRN	Start: S			Instructions:	Keep at the bedside to administer per physician's orders.		  	epINEPHrine (ADRENALIN) 1 mg/1 mL injection 0.3 mg	Dose: 0.3 mg	Route: subcutaneous	once PRN	Start: S			Instructions:	Keep at the bedside to administer per physician's orders.				Week 1	Perform every 1 day x1		Labs
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --				Week 2	Perform every 1 day x1		Nursing Orders
  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --		  	RESEARCH - HEIGHT AND WEIGHT	Interval: --	Occurrences: --			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	ALKALINE PHOSPHATASE	Interval: --	Occurrences: --		  	ALBUMIN LEVEL	Interval: --	Occurrences: --		  	BILIRUBIN, TOTAL AND DIRECT	Interval: --	Occurrences: --		  	ALT (SGPT)	Interval: --	Occurrences: --		  	AST (SGOT)	Interval: --	Occurrences: --		  	ADENOVIRUS BY PCR	Interval: --	Occurrences: --		  	BK VIRUS BY PCR	Interval: --	Occurrences: --		  	CYTOMEGALOVIRUS BY PCR	Interval: --	Occurrences: --		  	EPSTEIN BARR VIRUS (EBV) BY PCR	Interval: --	Occurrences: --		  	JC VIRUS, QUANTITATIVE PCR	Interval: --	Occurrences: --			Labs
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --				Week 4	Perform every 1 day x1		Nursing Orders
  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --		  	RESEARCH - HEIGHT AND WEIGHT	Interval: --	Occurrences: --			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	ADENOVIRUS BY PCR	Interval: --	Occurrences: --		  	BK VIRUS BY PCR	Interval: --	Occurrences: --		  	CYTOMEGALOVIRUS BY PCR	Interval: --	Occurrences: --		  	EPSTEIN BARR VIRUS (EBV) BY PCR	Interval: --	Occurrences: --		  	JC VIRUS, QUANTITATIVE PCR	Interval: --	Occurrences: --			Labs
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --				Week 6	Perform every 1 day x1		Nursing Orders
  	VITAL SIGNS - T/P/R/BP	Interval: --	Occurrences: --		  	RESEARCH - HEIGHT AND WEIGHT	Interval: --	Occurrences: --			Labs
  	CBC WITH PLATELET AND DIFFERENTIAL	Interval: --	Occurrences: --		  	ALKALINE PHOSPHATASE	Interval: --	Occurrences: --		  	ALBUMIN LEVEL	Interval: --	Occurrences: --		  	BILIRUBIN, TOTAL AND DIRECT	Interval: --	Occurrences: --		  	ALT (SGPT)	Interval: --	Occurrences: --		  	AST (SGOT)	Interval: --	Occurrences: --		  	ADENOVIRUS BY PCR	Interval: --	Occurrences: --		  	BK VIRUS BY PCR	Interval: --	Occurrences: --		  	CYTOMEGALOVIRUS BY PCR	Interval: --	Occurrences: --		  	EPSTEIN BARR VIRUS (EBV) BY PCR	Interval: --	Occurrences: --		  	JC VIRUS, QUANTITATIVE PCR	Interval: --	Occurrences: --			Labs
  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --		  	RESEARCH STUDY SPECIMEN	Interval: --	Occurrences: --