Protocol Index	

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IP BORTEZOMIB / DEXAMETHASONE (EVERY 21 DAYS)	

Types:      ONCOLOGY TREATMENT
Synonyms:  BORTEZOMIB, VELCADE, MM, MULTIPLE, MYELOMA

Cycle 1	Repeat 1 time	Cycle length: 21 days	Day 1	Perform every 1 day x1		Provider Communication
  	ONC PROVIDER COMMUNICATION 5	Interval: Once	Occurrences: --	Comments:	Use baseline weight to calculate dose. Adjust dose for weight gains/losses of greater than or equal to 10%.
			Labs
☑	CBC WITH PLATELET AND DIFFERENTIAL	Interval: Once	Occurrences: --		☑	COMPREHENSIVE METABOLIC PANEL	Interval: Once	Occurrences: --		☑	MAGNESIUM LEVEL	Interval: Once	Occurrences: --		☐	LDH	Interval: Once	Occurrences: --		☐	URIC ACID LEVEL	Interval: Once	Occurrences: --			Nursing Orders
  	TREATMENT CONDITIONS 7	Interval: Once	Occurrences: --	Comments:	HOLD and notify provider if ANC LESS than 1000; Platelets LESS than 100,000.
			Nursing Orders
  	ONC NURSING COMMUNICATION 51	Interval: Once	Occurrences: --	Comments:	HOLD Bortezomib and notify provider if Hgb is LESS than or equal to *** g/dL.
			Vitals
  	ONC NURSING COMMUNICATION 50	Interval: Once	Occurrences: --	Comments:	1) Check vital signs (BP, temperature, pulse, and respirations) prior to and 30 minutes after Bortezomib administration.

2) If systolic BP, 30 minutes after Bortezomib infusion, drops more than 30 mmHg, or if systolic BP is less than 90, please contact MD.
			Pre-Medications
  	dexamethasone (DECADRON) tablet 40 mg	Dose: 40 mg	Route: oral	once for 1 dose						Chemotherapy
  	bortezomib (VelCADE) 1.3 mg/m2 in sodium chloride 0.9% chemo injection	Dose: 1.3 mg/m2	Route: subcutaneous	once for 1 dose			Offset: 30 Minutes	Instructions:	DRUG IS AN IRRITANT.  Administer drug slowly to prevent burning upon administration.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	BORTEZOMIB 3.5 MG INJECTION POWDER FOR SOLUTION	Medications	1.3 mg/m2	Main Ingredient	No	SODIUM CHLORIDE 0.9 % INJECTION SOLUTION	Base	 	Always	Yes					Day 4	Perform every 1 day x1		Vitals
  	ONC NURSING COMMUNICATION 50	Interval: Once	Occurrences: --	Comments:	1) Check vital signs (BP, temperature, pulse, and respirations) prior to and 30 minutes after Bortezomib administration.

2) If systolic BP, 30 minutes after Bortezomib infusion, drops more than 30 mmHg, or if systolic BP is less than 90, please contact MD.
			Pre-Medications
  	dexamethasone (DECADRON) tablet 40 mg	Dose: 40 mg	Route: oral	once for 1 dose						Chemotherapy
  	bortezomib (VelCADE) 1.3 mg/m2 in sodium chloride 0.9% chemo injection	Dose: 1.3 mg/m2	Route: subcutaneous	once for 1 dose			Offset: 30 Minutes	Instructions:	DRUG IS AN IRRITANT.  Administer drug slowly to prevent burning upon administration.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	BORTEZOMIB 3.5 MG INJECTION POWDER FOR SOLUTION	Medications	1.3 mg/m2	Main Ingredient	No	SODIUM CHLORIDE 0.9 % INJECTION SOLUTION	Base	 	Always	Yes					Day 8	Perform every 1 day x1		Vitals
  	ONC NURSING COMMUNICATION 50	Interval: Once	Occurrences: --	Comments:	1) Check vital signs (BP, temperature, pulse, and respirations) prior to and 30 minutes after Bortezomib administration.

2) If systolic BP, 30 minutes after Bortezomib infusion, drops more than 30 mmHg, or if systolic BP is less than 90, please contact MD.
			Pre-Medications
  	dexamethasone (DECADRON) tablet 40 mg	Dose: 40 mg	Route: oral	once for 1 dose						Chemotherapy
  	bortezomib (VelCADE) 1.3 mg/m2 in sodium chloride 0.9% chemo injection	Dose: 1.3 mg/m2	Route: subcutaneous	once for 1 dose			Offset: 30 Minutes	Instructions:	DRUG IS AN IRRITANT.  Administer drug slowly to prevent burning upon administration.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	BORTEZOMIB 3.5 MG INJECTION POWDER FOR SOLUTION	Medications	1.3 mg/m2	Main Ingredient	No	SODIUM CHLORIDE 0.9 % INJECTION SOLUTION	Base	 	Always	Yes					Day 11	Perform every 1 day x1		Vitals
  	ONC NURSING COMMUNICATION 50	Interval: Once	Occurrences: --	Comments:	1) Check vital signs (BP, temperature, pulse, and respirations) prior to and 30 minutes after Bortezomib administration.

2) If systolic BP, 30 minutes after Bortezomib infusion, drops more than 30 mmHg, or if systolic BP is less than 90, please contact MD.
			Pre-Medications
  	dexamethasone (DECADRON) tablet 40 mg	Dose: 40 mg	Route: oral	once for 1 dose						Chemotherapy
  	bortezomib (VelCADE) 1.3 mg/m2 in sodium chloride 0.9% chemo injection	Dose: 1.3 mg/m2	Route: subcutaneous	once for 1 dose			Offset: 30 Minutes	Instructions:	DRUG IS AN IRRITANT.  Administer drug slowly to prevent burning upon administration.	Ingredients:	Name	Type	Dose	Selected	Adds Vol.	BORTEZOMIB 3.5 MG INJECTION POWDER FOR SOLUTION	Medications	1.3 mg/m2	Main Ingredient	No	SODIUM CHLORIDE 0.9 % INJECTION SOLUTION	Base	 	Always	Yes